Ryan Elsebai

English 21003

Research Proposal

Mar. 19, 2025

The Regenerative Potential of Stem Cell Cloning in Biomedicine: An exploration into the biomedical advantages of utilizing stem cells in regenerative procedures and organ transplantation.

Stem cells and cloning are major advancements in biomedical science with the potential to transform regenerative medicine. My research will examine how these technologies can treat degenerative diseases, organ failure, and genetic disorders. Certain stem cells can develop into any cell type, making them useful for tissue repair and regeneration. Moreover, cloning methods like somatic cell nuclear transfer can create genetically identical cells or organisms, offering possibilities for personalized treatments and organ transplants without immune rejection. Beyond regeneration, these innovations impact drug development and disease modeling. Stem cells derived from patients enable the creation of disease models for conditions like Parkinson’s disease, Alzheimer’s disease, and diabetes, fostering better drug testing and personalized treatments. Therapeutic cloning could also provide a stable source of transplantable organs, addressing shortages. This research paper will explore scientific advancements, ethical debates, and regulatory policies to support responsible development of research in these fields for medical and societal progress.

By examining both the scientific advancements and ethical considerations of stem cell cloning, this study will help shape future regulatory frameworks that ensure these technologies are used responsibly. Additionally, the findings may have broad implications for improving treatments for degenerative diseases, reducing the organ transplant crisis, and enhancing drug discovery processes. Case studies of recent scientific studies and breakthroughs will be analyzed to evaluate the feasibility and safety of these technologies in clinical settings. Key studies, including those by Inagaki et al. (2025), Li et al. (2022), and others, will serve as the foundation for my evaluation. 

References: 

Gura, T. (2013). Cell biology: Does cloning produce better embryonic stem cells? Science, 340(6139), 1390. https://pubmed.ncbi.nlm.nih.gov/23788774/

Inagaki, S., Nakamura, S., Kuse, Y., Aoshima, K., Funato, M., Shimazawa, M., & Hara, H. (2025). Establishment of vascularized human retinal organoids from induced pluripotent stem cells. Stem Cells. Advance online publication. https://doi.org/10.1093/stmcls/sxae093

Mummery, C. L., & Roelen, B. A. J. (2013). Cloning human embryos. Nature, 498(7453), 174–175. https://doi.org/10.1038/498174a 

Li, Y., Guo, X., Tang, K., & Liu, C. (2022). Efficient and safe single-cell cloning of human pluripotent stem cells using microfluidics-based cell sorting. Nature Protocols. Advance online publication. https://pubmed.ncbi.nlm.nih.gov/36261632/